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August 2007, 330 pages , NIC Series Volume 36,

Abstract:

Publication Series of the John von Neumann Institute for Computing (NIC) NIC Series Volume 36: http://www.fz-juelich.de/nic-series/volume36/nic-series-volume36.pdf http://www.fz-juelich.de/nic-series/volume36/volume36.html From the Preface of the book is the following citation: "In 2007 the John von Neumann Institute for Computing (NIC) celebrates its 20th anniversary. During its two decades of existence, computer simulations have become an invaluable tool for researching biological systems. This was also the topic of the second annual workshop "From Computational Biophysics to Systems Biology." (CBSB07). About 110 researchers and students from all over the world met from May 2nd to May 4th, 2007 at the Research Centre J\"ulich and discussed physics-based approaches to systems biology. They emphasized the increasing importance of computing in Biology, Medicine and other life sciences. Complex diseases such as cancer or Alzheimer's, to name only two, can be understood only if we obtain an insight in the working of cells on the molecular level. The analysis of the huge amount of experimental data, together with the problem that some processes or molecules cannot be detected in experiments, require the use of simulations. However, the large number of components in a cell, the difficulties in understanding their dynamics, and the complex interactions between them, make such simulations extremely challenging. Problems such as the all-atom simulation of chromatin dynamics or of ribosomes and other supermolecular systems will require access to computerswith hundreds of Teraflops. In a "town hall" meeting the participants emphasized the role of supercomputers in obtaining a detailed understanding of the working of cells. They agreed that further progress will require the supercomputer centers to provide both increased computing capacity and improved support and accessibility."

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Open access and downloads at: http://www.fz-juelich.de/nic-series/volume36/volume36.html http://www.fz-juelich.de/nic-series/volume36/nic-series-volume36.pdf

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